normally it is a 4" opening at the flange and connects to a 3" PVC... but some older homes have 4" pvc pipe for sewer.
So far all correct info but this seems to cover it very well.
3" or 4" will work
With modern water saver toilets a 3" main horizontal drain line is best. Goes against most of the old established thoughts of bigger is better.
The vertical drop from the floor flange to the 90 degree turn is best to use 4". Gets stuff out of the toilet better which is the most common issue with the new commodes.
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